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pentobarbital will decrease the extent or result of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can reduce panobinostat concentrations by ~70% and bring ab